Table 3.
Synergistic effect of F105 with fluconazole and terbinafine on C. albicans strains. MIC and FIC are expressed in μg/mL.
| C. albicans strain | MIC (F105) | MIC (FLC) | FIC (F105) | FIC (FLC) | FICImin | EC50 (F105) | |
| F105 + Fluconazole (FLC) | K6631-19 | 512 | 32 | 16 | 8 | 0.28 | 9.47 |
| K5012-19 | 64 | 64 | 16 | 4 | 0.31 | 4.72 | |
| K5061-19 | 128 | 32 | 4 | 8 | 0.31 | 12.35 | |
| K4940-19 | 64 | 128 | 16 | 16 | 0.38 | 17.32 | |
| K5050-19 | 256 | 64 | 4 | 16 | 0.27 | 6.21 | |
| NCTC®885-653 | 64 | 64 | 16 | 16 | 0.5 | 27.89 | |
| C. albicans strain | MIC (F105) | MIC (TRB) | FIC (F105) | FIC (TRB) | FICImin | EC50 (F105) | |
| F105 + Terbinafine (TRB) | K6631-19 | 512 | 4 | 16 | 1 | 0.28 | 4.54 |
| K5012-19 | 64 | 32 | 16 | 8 | 0.5 | 21.58 | |
| K5061-19 | 128 | 16 | 8 | 2 | 0.56 | 26.6 | |
| K4940-19 | 64 | 16 | 4 | 4 | 0.31 | 3.1 | |
| K5050-19 | 256 | 8 | 64 | 2 | 0.5 | 5.86 | |
| NCTC®885-653 | 64 | 8 | 2 | 2 | 0.28 | 1.57 |