Figure 2.

A refined model of claudin-15 paracellular channels [25]. Claudin-15 monomers assemble into double-row strands and form paracellular channels. (A) Top view of six claudin-15 monomers assembling into a double-row strand. (B) Snapshot of the simulation system showing claudin-15 monomers assembled between adjacent lipid bilayers. The pore regions are marked with circles. The water density across the simulation system and averaged over ∼250 ns of MD simulations, is shown: (C) parallel to the two membranes crossing the pores in the middle and (D) normal to the two membranes and crossing the pores in the middle. Figure is taken from [25] with slight modification.