Figure 3.

Cell-specific microRNA-21 (miR-21) expression in cardiomyopathies. In fibroblasts (a), miR-21 can promote cardiac fibrosis and cardiac hypertrophy. In cardiomyocytes (b), miR-21 can protect against hypertrophy and apoptosis. In fibroblasts of the pressure-overloaded heart (a), miR-21 is up-regulated, but not in cardiomyocytes (b). MiR-21 is involved in heart remodeling in non-ischemic and diabetic cardiomyopathy by promoting cardiac fibrosis. Figure assembled according to [95,97,100,122].