Table 1.
International Society for Cutaneous Lymphomas (ISCL)/European Organization of Research and Treatment of Cancer (EORTC) tumor, node, metastases (TNM) classification of cutaneous lymphomas other than mycosis fungoides (MF)/Sézary syndrome (SS).
Skin (T) | T1 | Solitary Skin Involvement | |
---|---|---|---|
T1a | Solitary lesion <5 cm in diameter | ||
T1b | Solitary lesion ≥5 cm in diameter | ||
T2 | Regional skin involvement: multiple lesions limited to one body region or two contiguous body regions | ||
T2a | All disease encompassing a <15 cm diameter circular area | ||
T2b | All disease encompassing a 15 to ≤30 cm diameter circular area | ||
T2c | All disease encompassing a ≥30 cm diameter circular area | ||
T3 | Generalized skin involvement | ||
T3a | Multiple lesions involving two noncontiguous body regions | ||
T3b | Multiple lesions involving ≥3 body regions | ||
Lymph nodes (N) | N0 | No clinical or pathologic lymph node involvement | |
N1 | Involvement of one peripheral or central lymph node region that drains in an area of current or prior skin involvement | ||
N2 | Involvement of ≥2 peripheral or central lymph node regions or involvement of any lymph node region that does not drain in an area of current or prior skin involvement | ||
N3 | Involvement of central lymph nodes | ||
Viscera (M) | M0 | No evidence of extracutaneous non-lymph node disease | |
M1 | Extracutaneous non-lymph node disease present |
Adapted from Kim YH, Willemze R, Pimpinelli N, et al. TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 2007;110(2):480. [21].