Table 2.

Expression of spasmolytic polypeptide-expressing metaplasia (SPEM)-related genes in the gastric corpus mucosa of KO/PEG versus WT/PEG mice and in KO/NTZ versus KO/PEG mice. Numerous of these genes were overexpressed in KO/PEG mice, but most of these genes were not affected by NTZ. Green: significant change (adjusted p-value (q-value) < 0.05); red: non-significant change (q-value > 0.05).

		KO/PEG vs. WT/PEG		KO/PEG vs. KO/NTZ
Target_ID	Gene Symbol	log2 Fold Change	q-Value	log 2 Fold Change	q-Value
ENSMUST00000109344	Wfdc2	5.05	3.0814 × 10−15	−0.59	0.7467
ENSMUST00000115119	Muc4	5.03	4.0540 × 10−33	−0.26	0.4441
ENSMUST00000027675	Pigr	4.97	2.2607 × 10−54	0.04	0.9695
ENSMUST00000060833	Gpa33	4.18	4.7773 × 10−11	−0.01	0.9952
ENSMUST00000045706	Cftr	3.96	4.6493 × 10−24	−0.38	0.6774
ENSMUST00000017867	Wfdc2	3.84	8.4954 × 10−51	−0.49	0.3777
ENSMUST00000189314	Muc6	3.17	1.5584 × 10−20	−0.86	0.1857
ENSMUST00000033414	Slc6a14	3.10	7.2586 × 10−9	0.40	0.7606
ENSMUST00000023520	Muc13	3.03	3.6130 × 10−19	1.27	0.0156
ENSMUST00000166860	Gpa33	2.86	1.5576 × 10−10	0.34	0.7540
ENSMUST00000098668	Ceacam1	2.82	7.8390 × 10−16	−0.20	0.8293
ENSMUST00000165147	Muc5b	2.56	8.9582 × 10−13	1.35	0.0128
ENSMUST00000171080	Fignl1	2.49	0.0004	1.03	0.4641
ENSMUST00000189068	Ly6a	2.39	0.0001	−0.17	0.9288
ENSMUST00000022616	Clu	2.27	2.4223 × 10−25	−0.08	0.8968
ENSMUST00000061829	Cd14	2.20	2.2346 × 10−50	0.33	0.2595
ENSMUST00000024826	Tff2	2.05	5.3435 × 10−5	−0.63	0.2658
ENSMUST00000139156	Akr1b10	1.94	0.0068	0.16	0.9409
ENSMUST00000027366	Vil1	1.88	1.5339 × 10−30	0.17	0.6503
ENSMUST00000193391	Il18r1	1.79	0.0001	−0.16	0.9019
ENSMUST00000066723	Lgals4	1.67	1.6543 × 10−23	0.38	0.2317
ENSMUST00000005218	Cd44	1.67	0.0313	1.23	0.3969
ENSMUST00000011178	Slc5a1	1.59	2.2000 × 10−14	−0.24	0.5989
ENSMUST00000056117	Itga2	1.44	0.0005	0.82	0.2941
ENSMUST00000098666	Ceacam1	1.41	0.0017	0.68	0.4358
ENSMUST00000076648	Fcgbp	1.30	0.0050	0.67	0.4623
ENSMUST00000027015	Casp1	1.29	3.1977 × 10−5	0.43	0.4968
ENSMUST00000062451	Muc6	1.23	0.0004	−0.67	0.3267
ENSMUST00000017743	Krt20	1.18	2.5460 × 10−7	0.28	0.5581
ENSMUST00000161870	Glipr1	1.17	0.0058	0.01	0.9985
ENSMUST00000025647	Pga5	1.08	0.0007	0.12	0.8895
ENSMUST00000148005	Mmp12	0.87	0.0238	0.38	0.6441
ENSMUST00000032800	Tyrobp	0.87	1.0831 × 10−7	0.21	0.5450
ENSMUST00000200880	Cxcl17	0.73	1.0409 × 10−13	0.01	0.9697
ENSMUST00000111194	Cd44	0.59	0.0029	−0.03	0.9541
ENSMUST00000038069	Ceacam10	0.53	0.0009	0.28	0.3423
ENSMUST00000017530	Traf4	0.40	5.1315 × 10−6	−0.03	0.8775
ENSMUST00000034304	Hsd17b2	0.33	0.04474	−0.48	0.3913
ENSMUST00000049004	Anpep	−0.42	0.0000	0.01	1.7276
ENSMUST00000060747	Bhlha15	−1.19	2.0159 × 10−11	0.26	0.4639
ENSMUST00000025585	Gif	−2.11	1.3159 × 10−6	−0.48	0.6294
ENSMUST00000149623	Xbp1	−2.24	2.2991 × 10−7	0.36	0.7162
ENSMUST00000144955	Pgc	−10.43	6.6393 × 10−80	−0.86	0.2757