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DUX4 signalling in FSHD-affected skeletal muscle. A simplified overview of the various signalling activities of DUX4 discussed in this review is depicted. Red arrows indicate a confirmed direct downstream DUX4 transcriptional target. Abbreviation: ROS, reactive oxygen species; FSHD facioscapulohumeral muscular dystrophy; DUX4: double homeobox protein 4.
