Table 1.
Functional Enrichment Analysis for the DEGs of Different Groups of GSE95849
| DM vs CN | DPN vs CN | DPN vs DM | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Category | Term | Count | P-value | Term | Count | P-value | Term | Count | P-value |
| BP | GO:0006952~defense response | 56 | 8.29E-16 | GO:0006954~inflammatory response | 63 | 2.73E-13 | GO:0009611~response to wounding | 52 | 5.2E-08 |
| GO:0006954~inflammatory response | 39 | 7.92E-15 | GO:0009611~response to wounding | 85 | 7.92E-13 | GO:0007610~behavior | 45 | 9E-07 | |
| GO:0009611~response to wounding | 50 | 9.89E-15 | GO:0006952~defense response | 88 | 1.54E-10 | GO:0006954~inflammatory response | 35 | 1.5E-06 | |
| GO:0006955~immune response | 53 | 4.69E-12 | GO:0006955~immune response | 91 | 4.89E-09 | GO:0001775~cell activation | 31 | 6.2E-06 | |
| GO:0006935~chemotaxis | 22 | 1.21E-09 | GO:0045087~innate immune response | 27 | 3.05E-06 | GO:0006952~defense response | 51 | 1E-05 | |
| CC | GO:0005794~Golgi apparatus | 94 | 2.00E-05 | GO:0005794~Golgi apparatus | 94 | 2.00E-05 | GO:0000267~cell fraction | 63 | 0.003 |
| GO:0000267~cell fraction | 108 | 1.16E-04 | GO:0000267~cell fraction | 108 | 1.16E-04 | GO:0033267~axon part | 8 | 0.00574 | |
| GO:0031410~cytoplasmic vesicle | 70 | 1.96E-04 | GO:0031410~cytoplasmic vesicle | 70 | 1.96E-04 | GO:0009986~cell surface | 25 | 0.00748 | |
| GO:0031982~vesicle | 70 | 6.59E-04 | GO:0031982~vesicle | 70 | 6.59E-04 | GO:0012506~vesicle membrane | 14 | 0.00814 | |
| GO:0005624~membrane fraction | 81 | 8.56E-04 | GO:0005624~membrane fraction | 81 | 8.56E-04 | GO:0005625~soluble fraction | 23 | 0.0082 | |
| MF | GO:0019955~cytokine binding | 23 | 4.46E-06 | GO:0019955~cytokine binding | 23 | 4.46E-06 | GO:0032403~protein complex binding | 20 | 0.00062 |
| GO:0019904~protein domain specific binding | 45 | 2.16E-05 | GO:0019904~protein domain specific binding | 45 | 2.16E-05 | GO:0042379~chemokine receptor binding | 9 | 0.00092 | |
| GO:0004950~chemokine receptor activity | 9 | 1.92E-04 | GO:0004950~chemokine receptor activity | 9 | 1.92E-04 | GO:0008009~chemokine activity | 8 | 0.00291 | |
| GO:0019956~chemokine binding | 9 | 3.47E-04 | GO:0019956~chemokine binding | 9 | 3.47E-04 | GO:0008134~transcription factor binding | 35 | 0.00606 | |
| GO:0051020~GTPase binding | 18 | 0.001287 | GO:0051020~GTPase binding | 18 | 0.001287 | GO:0003700~transcription factor activity | 58 | 0.00697 | |
Abbreviations: DM, diabetes mellitus; CN, healthy controls; DPN, diabetic peripheral neuropathy; DEGs, differentially expressed genes; BP, biological process; CC, cellular component; MF, molecular function.