Table 7.
Top 20 differentially expressed genes upregulated in a comparison of tumour vs. F1 samples, ordered by fold change.
| Gene Symbol | PDX F1 Avg (log2) | Tumour Avg (log2) | F1 SD | Tumour SD | Fold Change | p-value |
|---|---|---|---|---|---|---|
| SERPINB5 | 8.0 | 5.3 | 1.0 | 0.9 | 6.6 | 8.96 × 10–6 |
| ABCA12 | 6.3 | 3.7 | 1.1 | 1.0 | 5.7 | 2.34 × 10–5 |
| GALNT5 | 9.0 | 6.5 | 2.1 | 1.7 | 5.6 | 4.14 × 10–2 |
| ASPM | 6.5 | 4.1 | 0.5 | 0.8 | 5.1 | 2.92 × 10–7 |
| AGR2 | 8.1 | 5.7 | 0.6 | 1.4 | 5.1 | 3.00 × 10–4 |
| ANLN | 7.9 | 5.7 | 0.5 | 0.9 | 4.6 | 2.66 × 10–5 |
| AFAP1-AS1 | 7.3 | 5.1 | 1.5 | 1.5 | 4.5 | 1.59 × 10–2 |
| TMEM45B | 8.9 | 6.9 | 1.0 | 0.8 | 4.1 | 1.10 × 10–3 |
| TPX2 | 7.1 | 5.1 | 0.5 | 0.9 | 3.9 | 6.64 × 10–5 |
| CCNA2 | 7.6 | 5.7 | 0.7 | 0.8 | 3.9 | 4.81 × 10–5 |
| TOP2A | 8.4 | 6.4 | 0.5 | 0.7 | 3.8 | 2.00 × 10–4 |
| FAM111B | 6.6 | 4.7 | 1.0 | 1.4 | 3.8 | 2.00 × 10–4 |
| S100A14 | 8.7 | 6.8 | 0.8 | 0.9 | 3.8 | 5.70 × 10–5 |
| CDK1 | 6.0 | 4.0 | 0.8 | 0.7 | 3.8 | 5.00 × 10–4 |
| FANCI | 6.7 | 4.8 | 0.6 | 0.9 | 3.7 | 2.36 × 10–5 |
| FUT2 | 7.0 | 5.1 | 1.0 | 0.7 | 3.6 | 6.00 × 10–4 |
| HIST1H2BM | 8.1 | 6.2 | 0.7 | 1.3 | 3.6 | 2.50 × 10–2 |
| CENPF | 6.8 | 4.9 | 0.3 | 0.6 | 3.6 | 3.70 × 10–7 |
| KIF11 | 6.8 | 5.0 | 0.6 | 0.8 | 3.5 | 2.87 × 10–5 |
| MKI67 | 7.7 | 5.91 | 0.49 | 0.79 | 3.5 | 1.00 × 10–4 |