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. 2020 Jan 28;25(3):558. doi: 10.3390/molecules25030558

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Screening of healthy donors for pre-existing antibodies against polyethylene glycol (anti-PEG IgG and IgM). Blood was collected from healthy donors (n = 28, 14 men and 14 women) and the sera were assessed for the presence of natural anti-PEG antibodies using a direct ELISA against immobilized PEG. The positive threshold was defined as 3 times the value of background for each antibody. Each positive result was confirmed by competition assay against PEGylated liposomes. Dashed line indicates the positive threshold for IgG and dotted line the positive threshold for IgM detection.