. 2020 Jan 28;25(3):558. doi: 10.3390/molecules25030558

Table 1.

Pharmacokinetics parameters.

Treat-ment #	Dose Liposomal MPS	R²	Terminal Half-Life	C_max	C_max/Dose	AUC_last	AUC_last/Dose	Cl_obs	MRT_last
Treat-ment #	mg	R²	h	µg/mL	µg/mL/mg	h*µg/mL	h*µg/mL/mg	mL/h	h
1	50	0.98	14	35	0.7	1262	25	38	25
2	100	0.98	17	68	0.7	2163	22	46	27
3	150	0.998	19	108	0.7	3922	26	35	27

* The calculated plasma volume for a female patient weighing 55 kg, measuring 164 cm and with 40% hematocrit is ~2 liters. AUC, Area Under the Curve; Cl, Clearance; MRT, Mean Residence Time; Vss, Volume of Distribution.