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. 2019 Oct 21;217(1):e20190832. doi: 10.1084/jem.20190832

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© 2019 Long et al.

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Figure 6. — T cell–expressed Nsd2 is required for clearance of chronic LCMV virus infection. Nsd2^CD4WT and Nsd2^CD4KO mice were infected with LCMV-cl13 and analyzed at indicated time points. (A and B) Tfh (A) and GC B cell (GCB; B) frequency and number were analyzed by flow cytometry at day 10 or 40. n = 8 for Tfh; n = 10 for GCB. Data were pooled from three independent experiments. (C) LCMV specific antibodies in serum were measured by ELISA at day 40 after infection. Data are representative of two independent experiments. (D) Virus load in the serum of mice after LCMV cl13 infection. n = 16. Data were pooled from three experiments. (E) Body weight before and after infection. Results are presented relative to original body weight (day 0). Data were pooled from three experiments. In A, B, and D, bars represent means, and dots represent individual mice. Statistical analysis was done with Student’s t test. Error bars show means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.