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. 2020 Nov 14;217(1):e20190456. doi: 10.1084/jem.20190456

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© 2019 Vitiello and Miller

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — Functions of IL-17 in cancer. (A) Tumor-promoting effects of IL-17 are directly attributable to increased molecular signaling, tissue remodeling, and angiogenesis while indirectly related to the recruitment of immunosuppressive immune cells. (B) Conversely, the tumor-protective effects of IL-17 are directly related to cancer cell apoptosis, antitumoral immune cell activation, and the induction of IFN-γ⁺γδ T cells and mixed Th1/Th17 cells. MDSC, myeloid-derived suppressor cell.