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. 2020 Nov 14;217(1):e20190456. doi: 10.1084/jem.20190456

Figure 2.

Figure 2.

Th17 and γδ T cell function in the IL-17 immune axis. The roles of IL-17, Th17, and γδ T cells in the tumor microenvironment. Th17 and γδ T cell polarity is dictated by the presence or absence of specific cytokines. IL-1, IL-12, IL-15, TLR ligation, and microbial antigens potentiate an antitumoral γδ T phenotype. IL-1, IL-6, IL-12, and T-bet expression promotes a cytotoxic and mixed Th1/Th17 cell phenotype. MDSC, myeloid-derived suppressor cell.