Figure 6.

CD20 nanoCAR eradicates CD20⁺ tumor in a murine xenograft model: (A) Tumor size measured by caliper. Data points shown are the means, error bars represent the SEM, and only significant results are indicated. **** p < 0.0001 by two-way ANOVA with Bonferroni’s multiple comparison test; (B) Bioluminescence images showing tumor burden in NSG mice at day 39 post RL inoculation; (C) Images showing tumor burden in NSG lice at day 39 post RL inoculation; (D) Expression of eGFP in T cells transduced with the CD20-1-4_1BB:ζ naoCAR pre-intravenous injection and in T cells circulating in blood on day 35 post RL injection (day 17 post CAR T cell injection). Plot shown is representative for five mice.