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. 2020 Feb 6;17(3):1035. doi: 10.3390/ijerph17031035

Table 3.

Gene ontology identification of biological processes common to (a) T2D and AD (b) T2D and ALS (c) T2D and CP (d) T2D and ED (e) T2D and HD (f) T2D and MS and (g) T2D and PD.

(a) Common significant GOs of T2D and AD
GO ID Pathway p -Value
GO:0032000 positive regulation of fatty acid beta-oxidation 5.99 ×10−3
GO:0016064 immunoglobulin mediated immune response 6.73 ×10−3
GO:2000269 regulation of fibroblast apoptotic process 6.73 ×10−3
GO:0031998 regulation of fatty acid beta-oxidation 8.22 ×10−3
GO:0051588 regulation of neurotransmitter transport 1.05 ×10−2
GO:0007498 mesoderm development 1.64 ×10−2
GO:0051961 negative regulation of nervous system development 1.71 ×10−2
GO:0046928 regulation of neurotransmitter secretion 2.08 ×10−2
(b) Common significant GOs of T2D and ALS
GO ID Pathway p -Value
GO:0006352 DNA-templated transcription, initiation 2.46 ×10−3
GO:0050870 positive regulation of T cell activation 4.48 ×10−3
GO:0048935 peripheral nervous system neuron development 1.01 ×10−2
GO:0021522 spinal cord motor neuron differentiation 1.01 ×10−2
GO:0021559 trigeminal nerve development 1.01 ×10−2
GO:2000145 regulation of cell motility 1.10 ×10−2
GO:0048665 neuron fate specification 1.15 ×10−2
GO:1902692 regulation of neuroblast proliferation 1.58 ×10−2
GO:0048663 neuron fate commitment 2.01 ×10−2
GO:2000177 regulation of neural precursor cell proliferation 2.15 ×10−2
GO:0014033 neural crest cell differentiation 2.30 ×10−2
GO:0045597 positive regulation of cell differentiation 3.23 ×10−2
GO:0051961 negative regulation of nervous system development 3.28 ×10−2
GO:0019228 neuronal action potential 3.42 ×10−2
GO:0021953 central nervous system neuron differentiation 4.68 ×10−2
GO:0050768 negative regulation of neurogenesis 4.82 ×10−2
(c) Common significant GOs of T2D and CP
GO ID Pathway p -Value
GO:0071363 cellular response to growth factor stimulus 5.47 ×10−3
GO:0048681 negative regulation of axon regeneration 6.38 ×10−3
GO:0070571 negative regulation of neuron projection regeneration 7.18 ×10−3
GO:0099590 neurotransmitter receptor internalization 8.77 ×10−3
GO:0048679 regulation of axon regeneration 8.77 ×10−3
GO:0021952 central nervous system projection neuron axonogenesis 8.77 ×10−3
GO:0008045 motor neuron axon guidance 8.77 ×10−3
GO:0106030 neuron projection fasciculation 8.77 ×10−3
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 1.67 ×10−2
GO:0071875 adrenergic receptor signaling pathway 1.67 ×10−2
GO:1990090 cellular response to nerve growth factor stimulus 1.82 ×10−2
GO:0010977 negative regulation of neuron projection development 4.08 ×10−2
GO:0016192 vesicle-mediated transport 4.18 ×10−2
GO:0001934 positive regulation of protein phosphorylation 4.22 ×10−2
(d) Common significant GOs of T2D and ED
GO ID Pathway p -Value
GO:0006897 endocytosis 6.45 ×10−3
GO:0007599 hemostasis 1.15 ×10−2
GO:0090286 cytoskeletal anchoring at the nuclear membrane 1.30 ×10−2
GO:0034214 protein hexamerization 1.44 ×10−2
GO:0034063 stress granule assembly 1.73 ×10−2
GO:0097205 renal filtration 1.73 ×10−2
GO:0035278 miRNA mediated inhibition of translation 1.73 ×10−2
GO:0071470 cellular response to osmotic stress 2.15 ×10−2
GO:0034656 nucleobase-containing small molecule catabolic process 2.30 ×10−2
GO:0021953 central nervous system neuron differentiation 4.68 ×10−2
(e) Common significant GOs of T2D and HD
GO ID Pathway p -Value
GO:0042127 regulation of cell proliferation 6.92 ×10−5
GO:0022409 positive regulation of cell-cell adhesion 2.16 ×10−4
GO:0048665 neuron fate specification 5.19 ×10−3
GO:0048663 neuron fate commitment 9.06 ×10−3
GO:0014033 neural crest cell differentiation 1.04 ×10−2
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 1.49 ×10−2
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 2.65 ×10−2
GO:0007399 nervous system development 3.43 ×10−2
(f) Common significant GOs of T2D and MS
GO ID Pathway p -Value
GO:0070229 negative regulation of lymphocyte apoptotic process 4.32 ×10−4
GO:0099590 neurotransmitter receptor internalization 5.27 ×10−4
GO:0051588 regulation of neurotransmitter transport 8.67 ×10−4
GO:0050804 modulation of chemical synaptic transmission 2.29 ×10−3
GO:0046928 regulation of neurotransmitter secretion 3.50 ×10−3
GO:2000146 negative regulation of cell motility 3.66 ×10−3
GO:0090181 regulation of cholesterol metabolic process 7.75 ×10−3
GO:0072657 protein localization to membrane 1.43 ×10−2
GO:0007005 mitochondrion organization 1.60 ×10−2
GO:0010595 positive regulation of endothelial cell migration 2.11 ×10−2
GO:0010646 regulation of cell communication 2.17 ×10−2
GO:0050658 RNA transport 2.70 ×10−2
GO:0010628 positive regulation of gene expression 3.43 ×10−2
GO:2000145 regulation of cell motility 4.71 ×10−2
GO:0014033 neural crest cell differentiation 4.92 ×10−2
(g) Common significant GOs of T2D and PD
GO ID Pathway p -Value
GO:0070486 leukocyte aggregation 9.16 ×10−3
GO:0070584 mitochondrion morphogenesis 1.14 ×10−2
GO:0090128 regulation of synapse maturation 1.26 ×10−2
GO:0045624 positive regulation of T-helper cell differentiation 1.37 ×10−2
GO:0048854 brain morphogenesis 1.37 ×10−2
GO:0019228 neuronal action potential 2.73 ×10−2
GO:0097061 dendritic spine organization 2.84 ×10−2
GO:0030199 collagen fibril organization 3.40 ×10−2
GO:0061448 connective tissue development 3.51 ×10−2
GO:0048813 dendrite morphogenesis 3.73 ×10−2
GO:0099601 regulation of neurotransmitter receptor activity 3.84 ×10−2