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Effects of different thresholds for absolute enzyme activity increase (%WT) as the only criterion for defining amenability of GLA variants when comparing data from the in-house assay and the GLP-validated assay.
| Absolute Increase in α-Gal A Activity (%WT) to Define DGJ Amenability | Number (%) of GLA Variants Classified Differently between the GLP-Validated Assay and the In-House Assay; n = 178 |
|---|---|
| 3% | 19 (10.7) |
| 5% | 22 (12.4) |
| 7% | 16 (9.0) |
| 8% | 17 (9.6) |
| 10% | 20 (11.2) |
