Table 4.
Examples of lncRNA interacting with DNA and their postulated function.
|
LncRNA | Interacting DNA Region | Function |
| AIR | Slc22a3 promoter [113] | Epigenetic control of gene expression | |
| FENDRR | Foxf1, Pitx2 promoters [114,115] | ||
| TUNA | Nanog, Sox2 and Fgf4 promoters [116] | ||
| MEG3 | TGF-β pathway genes [117] | ||
| PARTICLE | Upstream of MATSA promoter [118] | ||
| NEAT1 | Multiple binding sites [119,120] | Paraspecle formation | |
| MALAT1 | Multiple binding sites [121] | Alternative splicing regulation, promotes metastasis | |
| LncRNA DHFR | DHFR promoter [122,123] | Transcription regulation | |
| TERRA | Telomers [124,125,126] | Telomer replication control |