Table 1.

Most representative tumor suppressor miRNAs and OncomiR (orange) involved in melanoma metastasis.

miRNA	Function	Target	References
miR-9	Tumor suppressor	NF-κB1-SNAIL1	[74]
miR-18b	Tumor suppressor	MDM2	[75]
miR-22	Tumor suppressor	MMP14 and SNAIL	[76]
miR-26a	Tumor suppressor	MITF	[77]
miR-34	Tumor suppressor	c-Kit	[57]
miR-30a 5p	Tumor suppressor	SNAIL, Sox4	[78,79]
miR-34b	Tumor suppressor	MET	[80]
miR-34c	Tumor suppressor	MET	[80,81]
miR-137	Tumor suppressor	MITF; PIK3R3	[82,83]
miR-148	Tumor suppressor	MITF	[84]
miR-145 5p	Tumor suppressor	TLR4; Oct4, Sox2, c-Myc	[85]
miR-138	Tumor suppressor	HIF1α	[86,87]
miR-150 5p	Tumor suppressor	SIX-1	[88]
miR-128	Tumor suppressor	TERT	[89]
miR-125a	Tumor suppressor	Lin28B	[90]
miR-193 b	Tumor suppressor	CCND1	[91,92]
miR-199 3p	Tumor suppressor	MET	[93]
miR-145 5p	Tumor suppressor	TLR4	[94]
miR-124	Tumor suppressor	RLIP76	[95]
miR-125b	Tumor suppressor	C-jun	[96]
miR-155	Tumor suppressor	SKI	[97]
miR-146a	Tumor suppressor	ITGAV and ROCK1	[98,99]
miR-194	Tumor suppressor	GEF-H1/RhoA	[100]
miR-199-3p	Tumor suppressor	mTOR and c-Met	[101]
miR- 200c	Tumor suppressor	BMI-1	[102]
miR- 205 5p	Tumor suppressor	E2F1 and E2F5	[103]
miR-211	Tumor suppressor	AP1S2, SOX11, IGFBP5, SERINC3, RAP1A	[104]
miR-203	Tumor suppressor	BMI-1; SLUG	[105,106,107]
miR-218	Tumor suppressor	CIP2A, BMI-1, CREB1, MITF	[108,109]
miR-224	Tumor suppressor	PIK3R3/AKT3	[110]
miR-365	Tumor suppressor	NRP1	[111]
miR-339 3p	Tumor suppressor	MCL-1	[112]
miR-338-3p	Tumor suppressor	MACC1	[113]
miR-340	Tumor suppressor	MITF	[114]
miR-339 3p	Tumor suppressor	MCL1	[112]
miR-429	Tumor suppressor	AKT	[115]
miR-579 3p	Tumor suppressor	BRAF, MDM2	[116]
miR-524 5p	Tumor suppressor	BRAF, ERK2	[117]
miR-542 3p	Tumor suppressor	PIM1	[118]
miR-605 5p	Tumor suppressor	INPP4B	[119]
miR-675	Tumor suppressor	MTDH	[120]
let7i	Tumor suppressor	ITGB3	[121]
let-7a	Tumor suppressor	ITGB3	[122]
let-7b	Tumor suppressor	BSG; Cyclin D1/D3	[121,122]
miR-10b	OncomiR	ITCH	[123]
miR-17	OncomiR	ETV1	[124]
miR-19	OncomiR	PITX1	[125]
miR-21	OncomiR	TIMP3, PTEN, PDCD4, FBXO11; TP53	[126,127,128]
miR-25	OncomiR	DKK3; RBM47	[129,130]
miR-30d	OncomiR	GALNT7	[131]
miR-30b	OncomiR	GALNT7	[131]
miR-125b	OncomiR	NEDD9	[132]
miR-146a	OncomiR	NUMB	[99]
miR-182	OncomiR	MITF, FOXO3, MTSS1	[133]
miR-214	OncomiR	TFAP2C	[134]
miR-224	OncomiR	TXNIP	[135]
miR-199a 5p	OncomiR	ApoE; DNAJA4	[136]
miR-199a 3p	OncomiR	ApoE; DNAJA4	[136]
miR-221	OncomiR	c-KIT, P27KIP1	[137,138,139]
miR-222	OncomiR	c-KIT, P27KIP1	[137,138,139]
miR-340	OncomiR	MITF	[114]
miR-373	OncomiR	SIK1	[140]
miR-452	OncomiR	TXNIP	[135]
miR-519d	OncomiR	EphA4	[141]
miR-532 5p	OncomiR	RUNX3	[142]
miR-638	OncomiR	TP53, INP2	[143]
miR-1908	OncomiR	ApoE; DNAJA4	[136]