Table 1.
A list of different curcumin nanocarriers with their characteristics and applications under in vitro and in vivo settings.
| Polymer | Size | Zeta Potential | LC or EE | Cell Line/Animal Model | Advantages | Refs. |
|---|---|---|---|---|---|---|
| BSA@CUR NPs | 92.59 ± 16.75 nm | −9.19 mV | 18.3% | MCF-7 cells | Increased therapeutic efficacy | [77] |
| Curcumin in BSA-dextran NP | 115 nm | 2.8% | Caco-2 cells | Better stability Improve the cellular antioxidant activity of curcumin |
[91] | |
| Curcumin cross-linked HSA NPs | 125 nm | −12.36 ± 0.73 to −10.88 ± 0.6 mV | was dependent on the particle size | A549 cells | Improved cellular uptake Increased the cytotoxicity |
[92] |
| Curcumin-loaded zein NPs | 66 nm | +17.1 mV | 7.3 ± 0.1% | GIT model | May be useful for application in functional foods or beverages | [93] |
| Curcumin-zein/rhamnolipid complex | 77.29 nm | −31 mV To +3 mV | EE: 98.05% | In vitro simulated gastrointestinal tract | Protect hydrophobic bioactive compounds | [94] |
| Pectin-coated CZ NPs | 250 nm to 600 nm | −45 to −50 mV | 5% | Simulated gastrointestinal digestive condition | Enhanced antioxidant activity in an aqueous environment | [95] |
| Curcumin-loaded zein NPs with (SC) and (SA) | 190 nm | 17 mV to 19.8 mV | EE: 36.10% to 76.06% | Improving the water solubility Improving photochemical stability improving antioxidant activity |
[96] | |
| Curcumin-loaded silk fibroin NPs | 155 nm to 170 nm | −45 mV | EE: 50% | Kelly Cells | Higher efficacy in cytotoxicity | [7] |
| Curcumin plus SFNs | 71 ± 10 nm | 1.50 ± 0.11 to 11.40 ± 0.76 | In vitro model of osteoarthritis | Exhibited a synergistic antioxidant effect Improve cyto- and hemo-compatibility |
[97] | |
| CUR-loaded silk NPs | 229 nm to 2286 nm | −17.8 nm to −18.9 mV | 22 to 41% | Rats | Longer plasma circulation time | [98] |
| CUR Loaded RBA−CS NPs | 778 nm | Negative | EE: 93.56% | Caco-2 cells | A great potential application for hydrophobic active agent delivery | [99] |
| Zein-HA NPs | 186.4 nm | –35.2 to −28.7 mV | 3.66% | Simulate gastrointestinal digestion | Better stability of anti-light degradation, and control release | [100] |
| SSPS NPs | 200 nm to 300 nm | EE: 90% | HCT116 and MCF-7 cells | Improved activity Improvement in the anti-proliferative activity |
[101] | |
| Cur-ACRU/CS NPs | 200 nm to 450 nm | +15 mV | 5.4% | Caco-2 cells | Improved permeability efficiency of free curcumin | [102] |
| Cur-Chitosan NPs | 167 nm to 251 nm | + 18.1 to + 20.2 mV | EE: 80% | HaCaT cells | Superior drug release Enhanced transdermal permeation of curcumin A superior percentage of cell viability |
[103] |
| CDG-CANPs | 215 nm | −24.1 mV | 27% | Caco-2 cells | Improvement of physicochemical stabilities, digestibility, bioaccessibility and cellular uptake | [104] |
| CUR-AlgNP | 100-600 nm | −36.0± 0.4 | EE: 68.3% | HeLa and H9c2 | Kills the cancer cell lines at lower concentrations | [105] |
| Cur-CS/Alg NPs | 199 nm to 1120 nm | −30.8 mV to −10.8 mV | 0% to 27.4% | HaCaT cells | Improved the cellular uptake of curcumin | [106] |
| Starch NPs | < 250 nm | −30 mV | EE: 80% | Simulated gastric and intestinal fluids | Higher encapsulation efficiency | [107] |
| OSA starch loaded nano curcumin | 10 nm to 50 nm | HeLa cells | Anti-cancer potential Significant enhancement in cellular uptake Increase bioavailability More controlled release |
[108] | ||
| Curcumin-load film | 159 ± 31 nm in length and 2 nm in width. | Rat | Improved the regeneration of hair follicles And sebaceous glands of the skin Attenuated the bacterial growth |
[109] | ||
| Cur- NLCs | 500 nm | EE~58.8 ± 3.5 | Mouse | Reducing the pro-inflammatory cytokine levels in the skin | [110] | |
| ANC NPs | ≤150 nm | -31.2 ± 3.66 mV | EE > 90% | L929 and MCF-7 cells | Inhibit microbial growth Prevent preferential killing of cancer cells compared to normal cells |
[111] |
| WPI-Lac/EGCG NPs | 110 nm | 27 mV | Better protective effect on the breakdown of curcumin in Pickering emulsions More even droplet distribution Greater thermal stability Higher curcumin percentage retention |
[112] | ||
| CUR-Loaded Gel-mPEG Nanogels | 147 ± 5.2 nm | −12.8 ± 0.6 | 7.9 ± 0.2%, | HeLa cells | Improved solubility Enhanced therapeutic efficacy |
[113] |
| Curcumin-loaded BSA NPs | 150 nm | Negative | EE: 45% | Murine melanoma model | Increase in survival rate associated with a reduction in tumor size | [114] |
| Curcumin loading EWP | 59.25 nm to 431.3 nm | >+30 mV | 11.2 mg/g | Protect the antioxidant activity of encapsulated curcumin | [115] | |
| Curcumin-PECs | 264.0 ± 3.1 nm | EE: 53% | HCT116 cells | Induced cell cycle arrest Exhibited cytotoxic effect |
[116] |