Table 2.

Summary of monoclonal gammopathies of dermatological significance.

Disease/Condition	Dermatological presentation	Monoclonal gammopathy
Acquired cutis laxa	Lax, wrinkled, sagging, redundant, inelastic skin	IgG, IgA, light and/or heavy chain deposition disease
Scleromyxedema	Mucinosis, papular and sclerodermoid eruption	IgG (lambda) [30]
Light chain amyloidosis	Purpura, hemorrhagic bullous lesions	IgG (lambda) [31]
Nodular amyloidosis	Papulonodules	IgG, IgA [32]
Waldenstrom macroglobulinemia	Nonspecific ulcers, purpura, and urticarial lesions	IgM [33]
Cryoglobulin vasculitis	Palpable purpura	Type I (IgM) and mixed (IgM and IgG, few polyclonal) [34]
Schnitzler's syndrome	Rose or red macules, urticarial plaques	IgM (few have IgG component) [35]
Necrobiotic xanthogranuloma	Waxy, yellow, plaques, nodules	IgG (kappa) [36]
POEMS syndrome	Hyperpigmentation, glomeruloid hemangioma	IgA or IgG (lambda) [37]
Pyoderma gangrenosum	Pustules, ulcerated plaques	IgA [38]
Cold agglutinin disease	Livido reticularis, raynaud phenomenon, acrocyanosis, ulceration	IgM (kappa) (few have IgA, few polyclonal) [39]
Papular mucinosis	Small, generally localized, lichenoid papular lesions	IgG (lambda) [30]
Subcorneal pustular dermatosis	Vesiculopustular eruptions	IgA [40]
Erythema elevatum diutinum	Plaques, nodules often localized to extensor surfaces	IgA [41]
Scleredema	Thickened, indurated plaques, most often affecting trunk	IgG and IgA [42]