Table 2.
Immunoproteasome inhibitors.
| Name | Type | IC50 (nM) Against Immuno- and Constitutive-Proteasome [141] |
|||||
|---|---|---|---|---|---|---|---|
| LMP7 (β5i) | β5 | LMP2 (β1i) |
β1 | MECL-1 (β2i) |
β2 | ||
| ONX0914 | Epoxyketone | 39 | 422 | 287 | >12700 | 902 | 927 |
| KZR-616 | Epoxyketone | 39 | 688 | 131 | >10600 | 623 | 604 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.