Table 4.
Predictors of post-infarct left ventricular systolic dysfunction in a univariate and multivariable analysis.
| Variable | OR | 95% CI | p-Value |
|---|---|---|---|
| Univariate analysis: | |||
| WMSI at discharge (for a 1-point increase) | 8255.0 | 387.65–175,791.3 | <0.001 |
| LAD vs. non-LAD | 17.10 | 4.99–58.62 | <0.00001 |
| Anterior vs. nonarterior wall STEMI | 14.54 | 4.86–43.55 | <0.000003 |
| Abciximab use vs. no use | 2.80 | 1.29–6.07 | <0.01 |
| BNP at discharge (for a 100 pg/mL increase) | 1.81 | 1.44–2.28 | <0.000001 |
| CRP at 24 h after admission (for a 10 mg/L increase) | 1.62 | 1.29–2.03 | <0.00006 |
| BNP at admission (for a 100 pg/mL increase) | 1.48 | 1.06–2.05 | <0.03 |
| CRP at discharge (for a 10 mg/L increase) | 1.45 | 1.17–1.80 | <0.0008 |
| WBC 24 h after admission (for a 10³/µL increase) | 1.27 | 1.10–1.46 | <0.001 |
| LVESd at discharge (for a 1 mm increase) | 1.22 | 1.12–1.33 | <0.00001 |
| LVEDd at discharge (for a 1 mm increase) | 1.16 | 1.08–1.26 | <0.0002 |
| LVESVI at discharge (for a 1 mL/m² increase) | 1.15 | 1.09–1.20 | <0.0000003 |
| E/E’ at discharge (for a 1-point increase) | 1.13 | 1.03–1.24 | <0.01 |
| CK-MBmax (for a 10 U/L increase) | 1.10 | 1.05–1.15 | <0.00006 |
| Body mass index (for a 10 kg/m² increase) | 1.09 | 0.99–1.20 | 0.08 |
| LVEDVI at discharge (for a 1 mL/m² increase) | 1.07 | 1.04–1.10 | <0.00003 |
| TnImax (for a 1 ng/mL increase) | 1.06 | 1.03–1.10 | <0.0003 |
| WBC at admission (for a 10³/µL increase) | 1.06 | 0.94–1.20 | 0.313 |
| DT at discharge (for a 1 ms increase) | 0.97 | 0.96–0.99 | <0.002 |
| CRP at admission (for a 10 mg/L increase) | 0.96 | 0.09–5.19 | 0.698 |
| LVEF at discharge (for a 1% increase) | 0.70 | 0.62–0.79 | <0.0000002 |
| TIMI flow pre-PCI (for a 1-point increase) | 0.63 | 0.44–0.88 | <0.008 |
| S’ at discharge (for a 1 cm/s increase) | 0.45 | 0.32–0.64 | <0.00002 |
| Multivariable analysis (MA): | |||
| BNP at discharge (for a 100 pg/mL increase) | 1.44 | 1.11–1.84 | <0.0002 |
| LVEF at discharge (for a 1% increase) | 0.73 | 0.65–0.83 | <0.00002 |
| MA with LVEF at discharge excluded: | |||
| LAD vs. non-LAD | 7.36 | 1.95–27.7 | <0.004 |
| BNP at discharge (for a 100 pg/mL increase) | 1.59 | 1.26–2.01 | <0.0002 |
| CRP at 24 h after admission (for a 10 mg/L increase) | 1.47 | 1.10–1.97 | <0.01 |
Univariate analysis shows parameters from Table 1 and Table 2 with a p-value < 0.01, as well as high-sensitivity C-reactive protein and leukocyte count independent of a p-value. Results are presented according to decreasing values of odds ratios. Abbreviations: BNP—B-type natriuretic peptide; CI—confidence interval; CK-MBmax—maximal activity of isoenzyme MB of creatine kinase; CRP—high-sensitivity C-reactive protein; DT—deceleration time of early transmitral flow; E—peak velocity of early transmitral flow; E’—average peak early diastolic mitral annular velocity; LAD—infarct-related left descending artery; LVEDd—left ventricular end-diastolic diameter; LVEDVI—left ventricular end-diastolic volume index; LVEF—left ventricular ejection fraction; LVESd—left ventricular end-systolic diameter; LVESVI—left ventricular end-systolic volume index; OR—odds ratio; S’—average peak systolic mitral annular velocity; STEMI—ST-segment elevation myocardial infarction; TIMI—Thrombolysis in Myocardial Infarction score; TnImax—maximal concentration of troponin I; WBC -leukocyte count; WMSI—wall motion score index.