Table 3.
The MICs (µM) of the designed peptides against E. coli ATCC25922 in the presence of physiological salts.
| Peptides | Control 1 | Physiological Salts 2 | |||||
|---|---|---|---|---|---|---|---|
| NaCl | KCl | NH4Cl | MgCl2 | ZnCl2 | FeCl3 | ||
| IRGG | 8 | 64 | 8 | 8 | 16 | 16 | 8 |
| IRpG | 4 | 32 | 4 | 4 | 8 | 4 | 4 |
| FRGG | 8 | 64 | 8 | 8 | 16 | 16 | 8 |
| FRpG | 8 | 32 | 8 | 8 | 8 | 8 | 8 |
| LRGG | 2 | 8 | 2 | 2 | 4 | 2 | 2 |
| LRpG | 2 | 8 | 2 | 2 | 2 | 2 | 2 |
| LRα | 2 | 8 | 2 | 2 | 2 | 2 | 2 |
| Melittin | 1 | 4 | 1 | 1 | 1 | 1 | 1 |
1 The control MICs were determined in Mueller–Hinton broth MHB medium without physiological salts. 2 The final physiological concentrations of NaCl, KCl, NH4Cl, MgCl2, ZnCl2, and FeCl3 were 150 mM, 4.5 mM, 6 μM, 1 mM, 8 μM, and 4 μM, respectively. The data are based on at least three independent experiments.