| T2DM | type 2 diabetes mellitus |
| BBB | blood—brain barrier |
| FGF21 | fibroblast growth factor 21 |
| rFGF21 | recombinant fibroblast growth factor 21 |
| FGFR1 | fibroblast growth factor receptor 1 |
| PPARγ | peroxisome proliferator-activated receptor gamma |
| dMCAO | distal middle cerebral artery occlusion |
| HBMEC | human brain microvascular endothelial cell |
| IL-1β | interleukin-1β |
| FITC | fluorescein isothiocyanate |
| EMSA | electrophoretic mobility shift assay |
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