Figure 1.

Structural organization of the Ras guanine-nucleotide releasing proteins (RasGRPs) with amino acide sequence annotation for RasGRP2. The protein domains indicated are the Ras exchange motif (REM), catalytic domain (CDC-25), calcium-binding helix(E)-loop-helix(F) hands (EF), diacylglycerol-binding domain (C1) and the RasGRP1 specific C-terminal coil-coil domain (CC). Circled P and red numbers correspond to phosphorylation sites on serine residues involved in RasGRP2 activity regulation.