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. 2020 Jan 31;21(3):934. doi: 10.3390/ijms21030934

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of KBs on Aβ transport across BBB. (A) Schematic representation of the human in vitro BBB model used for (A) apical-to-basolateral (red arrow) and (C) basolateral-to-apical (green arrow) Aβ transport. After 48 h of treatment with KBs, Aβ_1–40Cy5 or [³H]inulin was added to the (B) apical compartment or (D) basolateral compartment, incubated for 30 min, and permeability was then assessed. The data represent the mean ± SEM obtained from at least three independent experiments relative to the control conditions, each of which was performed in triplicate (*** p < 0.001).