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. 2020 Jan 29;21(3):858. doi: 10.3390/ijms21030858

Figure 3.

Figure 3

Median steady-state tacrolimus trough concentrations during the first 15 days post-transplant for CYP3A4/5 and ABCB1 SNPs. Associations between steady-state tacrolimus trough concentrations measured in 3-day intervals and CYP3A4/5 (A–C) and ABCB1 (D–F) SNPs were evaluated. The x-axis denotes time in 3-day intervals for the first 15 days post-transplant while the y-axis represents the median tacrolimus trough concentrations. The shaded area represents the goal tacrolimus trough concentration (5–10 ng/mL). Abbreviations: ABCB1, ATP-binding cassette B1; CYP3A4/5, cytochrome P450 isoforms 4 and 5; SNP, single nucleotide polymorphisms.