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. 2020 Jan 29;21(3):858. doi: 10.3390/ijms21030858

Figure 4.

Figure 4

Time to target steady-state tacrolimus trough concentrations for CYP3A4/5 and ABCB1 SNPs. Time to target tacrolimus trough concentration, stratified by genotypes, are presented using Kaplan Meier curves, where the y-axis denotes the percentage of patients who reached a steady-state trough between 5 and 10 ng/mL while the x-axis denotes days post-transplant. Subjects at risk for not achieving tacrolimus target trough concentrations are shown on days +10, +20, and +30 post-transplant. SNPs shown below are CYP3A5*3 (A), CYP3A4*1b (B), CYP3A4*22 (C), ABCB1 C1236T (D), ABCB1 C2677T (E), and ABCB1 C3435T (F). p < 0.05 was considered significant, and p values were adjusted for multiple comparisons using a Bonferroni correction. Abbreviations: ABCB1, ATP-binding cassette B1; CYP3A4/5, cytochrome P450 isoforms 4 and 5; SNP, single nucleotide polymorphisms.