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IL-1β. IL-1β mRNA expression (A) in vitro following inflammatory and hypoxic incubation, and (B) in vivo at different timepoints. (C) Association between LLS and IL-1β mRNA expression (n-fold change) at 3883 m a.s.l. after 24 h. * p ≤ 0.05 and ** p < 0.01 vs. baseline (Munich 520 m or normoxic control in vitro), x p ≤ 0.05 vs. CD3/CD28-stimulation, p ≤ 0.05 vs. prior time point in vivo (n.s.). IL-1β = Interleukin 1β. LLS = Lake Louise Score.
