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. 2020 Feb 5;21(3):1045. doi: 10.3390/ijms21031045

Figure 1.

Figure 1

The result produced by our SNP_TATA_Comparator [45] in the case of the only known clinical SNP marker (rs1427119663) of slowed atherosclerosis in the human CETP gene. Legend: (a) Unannotated SNPs (analyzed in this study) in a 70 bp proximal promoter [where all proven TBP-sites (framed, □) are located (double-headed red arrow, ↔) of the human CETP gene retrieved from the UCSC Genome Browser [13]. (b) The description of this clinical SNP marker (rs1427119663) of retarded atherosclerosis corresponds to dbSNP build No. 151 [12]. (c) The output of our public Web service SNP_TATA_Comparator [45] after the input of data on the clinical SNP marker rs1427119663 as depicted by arrows (i.e., the textbox Result: “deficiency: significant” in line “Decision”). (d) Our software-based calculation implementing our bioinformatics model of the three-step TBP-promoter binding (i.e., TBP slides along DNA <=> TBP stops at a TBP-site <=> the TBP-promoter complex is fixed by a 90° DNA bend [36]), based on standard bioinformatics-related software R [59], as described in detail within Supplementary Materials (Supplementary File S1: Supplementary Methods).