Table 2.

Atherogenesis-related candidate SNP markers within the gene promoters where SNPs of TBP-sites are clinically linked with cardiovascular diseases.

Gene	dbSNP ID [12] or [Ref]	DNA, Genome Sequence				KD, nM						Clinical Data or Candidate SNP Markers	AS	Ref.
		5′ flank	WT	min	3′ flank	WT	min	Δ	Z	α	ρ
CETP	rs1427119663	cgtgggggct	18bp	-	gggctccagg	4	7	<	7	10−6	A	hyperalpha-lipoprotei-nemia (athero-protector)	↓	[58]
	rs1002690375	gggccactta	c	t	acaccactgc	4	2	>	11	10−6	A	accelerated atherogenesis, which can be slowed down by swimming	↑	[61,62]
	rs757176551	catatacggg	c	g	tccaggctga	4	2	>	10	10−6	A		↑
	rs569033466	atacatatac	g	a, t, c	ggctccaggc	4	3	>	4	10−3	B		↑
	rs1451694749	catacatata	c	t	gggctccagg	4	2	>	12	10−6	A		↑
MBL2	rs72661131	tctatttcta	t	c	tatagcctgc	2	4	<	12	10−6	A	stroke, pre-eclampsia, variable immune-deficiency	↑	[64,65,66]
	rs1471733364	tatttctata	t	g	agcctgcacc	2	5	<	15	10−6	A	on the Western diet, MBL2 deficit and excess quicken earlier and late atherogenesis, respectively	↑	[67,68,69]
	rs562962093	atctatttct	a	g	tatagcctgc	2	5	<	15	10−6	A		↑
	rs567653539	tttctatata	g	a	cctgcaccca	2	1	>	4	10−3	B		↑
F3	rs563763767	ccctttatag	c	t *	gcgcggggca	3	2	>	6	10−6	A	myocardial infarction, thrombosis	↑	[70]
	rs1439518731	gccctttata	-	ta	gcgcgcgggg	3	1	>	12	10−6	A	accelerated atherogenesis that can be slowed down by aspirin slowed down atherogenesis	↑	[71,72]
	rs966076891:t	gccgccggcc	c	t	tttatagcgc	3	2	>	6	10−6	A		↑
	rs966076891:g	gccgccggcc	c	g	tttatagcgc	3	4	<	2	0.05	D		↓	[73]
	rs1190659847	gccggccctt	t	c	atagcgcgcg	3	12	<	19	10−6	A		↓
TPI1	rs1800202	gcgctctata	t	g	aagtgggcag	1	4	<	17	10−6	A	hemolytic anemia, neu-romuscular diseases	↑	[74,75]
	rs1386262216	gcggcgctct	a	c, g	tataagtggg	1	2	<	8	10−6	A	traumatic and ischemic co-mplications of atherogenesis	↑	[76,77]
	rs781835924	cgcggcgctc	t	c	atataagtgg	1	2	<	10	10−6	A		↑

Notes. Hereinafter, Alleles: wt, ancestral; min, minor; “-”, deletion. K_D, dissociation constant of the TBP–DNA complex; α = 1 – p, significance (where p value is given in Figure 1); Gene expression changes (Δ): an increase (>) and decrease (<); Atherogenesis (AS): accelerated (↑) and slowed down (↓); ρ, heuristic rank of candidate SNP markers from the “best” (A) to the “worst” (E). * This SNP also includes other neutral alleles. Diseases: RA, rheumatoid arthritis. Genes: CETP, cholesteryl ester transfer protein; MBL2, mannose-binding lectin 2 (synonyms: collectin-1); F3, coagulation factor III (synonyms: thromboplastin, tissue factor); TPI1, triosephosphate isomerase 1. Deletions, CETP: 18bp = gggcggacatacatatac.