Table 3.

Atherogenesis-related candidate SNP markers within the gene promoters where SNPs of TBP-sites are clinically linked with blood disorders.

Gene	dbSNP ID [12] or [Ref]	DNA, Genome Sequence				KD, nM						Clinical Data or Prediction	AS	Ref.
		5′ flank	WT	min	3′ flank	WT	min	Δ	Z	α	ρ
HBB	rs33981098	agggctgggc	a	g, c	taaaagtcag	5	9	<	10	10−6	A	thalassemia, RM	↓	[78]
	rs33980857	gggctgggca	t	a, t, g	aaaagtcagt	5	21	<	27	10−6	A		↓
	rs397509430	gggctgggca	t	-	aaaagtcagt	5	29	<	34	10−6	A		↓
	rs34598529	ggctgggcat	a	g	aaagtcaggg	5	18	<	24	10−6	A		↓
	rs33931746	gctgggcata	a	g, c	aagtcagggc	5	11	<	14	10−6	A		↓
	rs281864525	tgggcataaa	a	c *	gtcagggcag	5	7	<	7	10−6	A	thalassemia is athero-protective	↓	[79]
	rs63750953	ctgggcataa	aa	-	gtcagggcag	5	8	<	9	10−6	A		↓
	rs1160543272:t	ccagggctgg	g	t	cataaaagtc	4.6	5.3	<	2	0.05	D		↓
	rs1160543272:a	ccagggctgg	g	a	cataaaagtc	4.6	3.8	>	3	10−2	C	norm (silent SNP), hemo-lytically extra-cellular HBB releases athe-rogenic heme	↑	[80,81]
	rs34500389	cagggctggg	c	t*	ataaaagtca	5	2	>	14	10−6	A		↑
	[80]	gctgggcata	a	t	aagtcagggc	5	3	>	8	10−6	A		↑
HBD	rs996092254	aggacaggac	c	t	agcataaaag	4	3	>	4	10−6	A		↑
	rs1473693473	ataaaaggca	a	g	ggcagagtcg	4	5	<	3	10−2	C	thalassemia athero-protective	↓	[79]
	rs34166473	aggaccagca	t	c	aaaaggcagg	4	12	<	18	10−6	A		↓
	rs35518301	caggaccagc	a	g	taaaaggcag	4	8	<	11	10−6	A	thalassemia, RM	↓	[78]
ACKR1	rs2814778	ttggctctta	t	c	cttggaagca	10	12	<	4	10−3	B	leukopenia, RM	↓	[82,83]
												slowed down atherogenesis		[84]
	rs1185314734	tggctcttat	c	g	ttggaagcac	10	6	>	8	10−6	A	accelerated atherogenesis	↑	[85]
NOS2	[30]	gtataaatac	t	c	tcttggctgc	1.7	1.4	>	3	10−2	C	RM	↑	[86,87]
												accelerated atherogenesis		[88,89]
	rs1339255364	gcatggggtg	a	g *	gtataaatac	1.7	2.0	<	2	0.05	D	slowed down atherogenesis	↓	[90]
F7	[91]	ccttggaggc	a	c	gagaactttg	53	62	<	3	10−2	C	moderate bleeding	↑	[91]
												atherogenesis slowed by dill		[92,93]
	rs749691733	agaactttgc	c	t	cgtcagtccc	53	66	<	4	10−3	B	F7 excess is a biomarker of hypercholes-terolemia, which accelerates atherogenesis, which can be slowed down by olive oil	↑	[94,95]
	rs997515289	ttggaggcag	a	c	gaactttgcc	53	68	<	5	10−3	B		↑
	rs549591993	gcccgtcagt	c	a	ccatggggaa	53	25	>	13	10−6	A		↑
	rs367732974	aactttgccc	g	a	tcagtcccat	53	47	>	2	0.05	D		↑
	rs777947114	agagaacttt	g	a	cccgtcagtc	53	19	>	19	10−6	A		↑
	rs1187329967	tggaggcaga	g	c	aactttgccc	53	32	>	9	10−6	A		↑
	rs770113559	gtcacccttg	g	a	aggcagagaa	53	41	>	5	10−6	A		↑
	rs781338265	cctctgtcac	c	a *	cttggaggca	53	30	>	11	10−6	A		↑
	rs754814507	cctcccccat	c	t	cctctgtcac	53	45	>	3	10−3	B		↑
	rs1296764751	tcccctcccc	c	t	atccctctgt	53	46	>	2	0.05	A		↑

Diseases: RM, resistance to malaria. Genes: HBB and HBD, hemoglobin subunits β and δ; ACKR1, atypical chemokine receptor; NOS2, nitric oxide synthase 2; F7, coagulation factor VII.