Table 6.

Atherogenesis-related candidate SNP markers within the gene promoters where SNPs of TBP-sites are clinically linked with cancers.

Gene	dbSNP ID [12] or [Ref]	DNA, Genome Sequence				KD, nM						Clinical Data or Candidate SNP Markers	AS	[Ref]
		5′ flank	WT	min	3′ flank	WT	min	Δ	Z	α	ρ
ADH7	rs17537595	gctgctgtta	t	c	atacaacaga	1	3	<	13	10−6	A	esophageal cancer	↑	[137]
	rs372329931	agctgctgtt	a	g	tatacaacag	1	3	<	13	10−6	A	post-esopha-gectomy necrosis comorbid with atherogenesis	↑	[138]
	rs755152695	caagctgctg	t	c	tatatacaac	1.0	1.4	<	4	10−3	B		↑
	rs1238877951	gcacaagctg	c	a	tgttatatac	1.0	1.2	<	3	10−2	C		↑
HSD17B1	rs201739205	aggtgatatc	a	c	agcccagagc	13	18	<	5	10−3	B	breast cancer	↓	[139]
	rs748743528	gcaggtgata	t	c	caagcccaga	13	28	<	13	10−6	A	biomarker of the atherogenesis slowed down by drug IMM-H007	↓	[140]
	rs779674159	agcaggtgat	a	t	tcaagcccag	13	35	<	18	10−6	A		↓
	rs1282820277	cgaagcaggt	g	a	atatcaagcc	13	7	>	9	10−6	A	accelerated atherogenesis	↑	[141]
	rs755636251	ggcgaagcag	g	t	tgatatcaag	13	11	>	2	0.05	D		↑
	rs1332869256	gggcgaagca	g	c	gtgatatcaa	13	11	>	4	10−3	B		↑
MLH1	rs63750527	tacaacaaag	g	c	ggacttcaga	11	9	>	4	10−3	B	nonpolyposis colon cancer	↓	[15]
	rs756099600	atacaacaaa	g	a, c	gggacttcag	11	10	>	3	0.05	D		↓
	rs753671152	caaaggggac	t	a	tcagaaatgt	11	9	>	4	10−3	B	improved DNA mismatch repair can slow down atherogenesis	↓	[142,143,144]
	rs1424963586	gatacaacaa	a	c	ggggacttca	11	9	>	3	10−2	C		↓
	rs752622244	cttggagggg	g	t	atacaacaaa	11	3	>	17	10−6	A		↓
	rs587778905	gcttggaggg	21bp	taaa	agaaatgtca	11	19	<	9	10−6	A	accelerated atherogenesis, which can be slowed down by restricting alcohol and red meat intake	↑
	rs34285587	gggggataca	a	g*	caaaggggac	11	20	<	9	10−6	A		↑
	rs864622145	ggagggggat	a	g	caacaaaggg	11	27	<	17	10−6	A		↑
RET	rs10900296	gccggcgctt	a	g, c	cctcgcttca	30	90	<	20	10−6	A	pheochro-mocytoma	↑	[15]
	rs551321384	agccggcgct	t	c	acctcgcttc	30	75	<	17	10−6	A	dysregulated atheroprotector pentraxin-3	↑	[145]
	rs1191017949	cagccggcgc	t	c	tacctcgctt	30	48	<	7	10−6	A		↑
	rs1237152255	tacctcgctt	c	t	ttacctcgct	30	20	>	6	10−6	A	slowed down atherogenesis	↓
	rs1372293149	cgcagccggc	g	a	cttacctcgc	30	16	>	10	10−6	A		↓
	rs10900297	gcgcttacct	c	a	gcttcagtcc	30	9	>	17	10−6	A	pheochro-mocytoma	↓	[15]
ESR2	rs35036378	cctctcggtc	t	g	ttaaaaggaa	6	8	<	5	10−3	B	ESR2-deficient pT1 tumor	↑	[146]
	rs766797386	ttaaaaggaa	g	t	aaggggctta	6	7	<	3	10−2	C	accelerated calcification	↑	[147,148]
DHFR	rs10168	ctgcacaaat	g	a	gggacgaggg	15	9	>	9	10−6	A	resistance to methotrexate	↓	[149]
	rs750793297	tgcacaaatg	g	t	ggacgagggg	15	13	>	3	10−2	C	DHFR deficit is a biomarker of accelerated atherogenesis, which can be slowed down by smoking restriction	↓	[150,151]
	rs1464445339	ggggcggggc	35bp	-	ggccacaatt	15	170	<	44	10−6	A		↑
	rs766799008	gcctgcacaa	a	g	tggggacgag	15	19	<	3	10−3	B		↑
	rs764508464	gcctgcacaa	a	-	tggggacgag	15	37	<	17	10−6	A		↑
	rs754122321	ctcgcctgca	c	g	aaatggggac	15	25	<	9	10−6	A		↑
	rs1328822484	cctcgcctgc	a	g	caaatgggga	15	58	<	25	10−6	A		↑

Genes: ADH7, alcohol dehydrogenase 7; HSD17B1, hydroxysteroid (17-β) dehydrogenase 1; MLH1, DNA mismatch repair protein Mlh1; RET, Ret proto-oncogene; ESR2, estrogen receptor 2 (β); DHFR, dihydrofolate reductase. Deletions, MLH1: 21bp = ggatacaacaaaggggacttc; DHFR: 35bp = ctcgcctgcacaaatggggacgaggggggcggggc.