Table 9.

Atherogenesis-related candidate SNP markers within the promoters of miRNA genes associated with instability of the atherosclerotic plaque.

Gene	dbSNP ID [12] or [Ref]	DNA, Genome Sequence				KD, nM						Clinical Data or Candidate SNP Markers	AS	Ref.
		5′ flank	WT	min	3′ flank	WT	min	Δ	Z	α	ρ
MIR10B	rs1388274194	cagcgaccta	g	t	cagcgaccta	14	4	>	14	10−6	A	ABCA1 over-inhibition that accelerates atherogenesis, which can be slowed down by dietary supplements of berberine	↑	[173,174]
	rs564940769	cggcagcgac	c	g *	taggtacctc	14	25	<	8	10−6	A	slowed atherogenesis	↓
MIR21	rs752908264	gtgacatctc	c	t	atggctgtac	33	17	>	11	10−6	A	reduced calcification of atherosclerotic plaque	↓	[175]
	rs781007656	atcgtgacat	c	a	tccatggctg	33	10	>	20	10−6	A		↓
	rs368618785	ctaccatcgt	g	t	acatctccat	33	10	>	20	10−6	A		↓
	rs772840282	actgtctgct	t	a	gttttgccta	33	22	>	7	10−6	A		↓
MIR143	rs369969688	cctctaacac	c	t	ccttctcctg	17	13	>	5	10−3	B	prevented transformation of cells over-loaded with cholesterol in-to foam cells slows down atherogenesis	↓	[176,177,178]
	rs142037609	tcccctctaa	c	t	accccttctc	17	5	>	17	10−6	A		↓
	rs1035277319	caggtcccct	c	a	taacacccct	17	5	>	16	10−6	A		↓
	rs999653534	ccaggtcccc	t	a	ctaacacccc	17	14	>	3	10−2	C		↓
	rs1369382070	caccccttct	-	c	cctggccagg	17	22	<	5	10−3	B	accelerated atherogenesis	↑	[179]
	rs568314295	ccctctaaca	c	g, t	cccttctcct	17	21	<	3	10−3	B		↑
	rs1033081876	cccctctaac	a	c	ccccttctcc	17	44	<	16	10−6	A		↑
MIR145	rs909856793	cagctggtcc	t	c	tagggacacg	45	56	<	3	10−3	B	accelerated atherogenesis	↑	[177,178,180]
	rs746241408	cttagggaca	c	a, t	ggcggccttg	45	38	>	3	0.05	D	prevented transformation of cells over-loaded with cholesterol in-to foam cells slows down atherogenesis	↓
	rs778670319	tccttaggga	c	t	acggcggcct	45	32	>	5	10−6	D		↓