Table 1.
IL-20: biological effects and target cells.
| Organ | Diseases | Target Cells | Role | Reference |
|---|---|---|---|---|
| Brain | Ischemic Stroke | Glia-like cells | ↑ Inflammation ↑ Ischemic infarction |
[162] |
| Mouth | Oral Cancer | Oral carcinoma cells | ↑ Tumor progression ↑ Inflammation |
[157] |
| Airway | Asthma | Lung epithelial cells | ↑ Lung fibrosis | [160] |
| Arterial | Atherosclerosis | Endothelial cells | ↑ Inflammation ↑ Angiogenesis ↑ Atherosclerosis |
[158] |
| Liver | Hepatocellular Carcinoma (HCC) | Liver cancer cells | ↑ Tumor progression | [163] |
| Liver Injury | Hepatocytes | ↑ Liver fibrosis ↑ Inflammation |
[164] | |
| Pancreas | Type 2 Diabetes | Pancreatic islets | ↑ Inflammation | [165] |
| Kidney | Hgcl2-Induced AKI | Proximal tubular epithelial cells | ↑ Inflammation ↑ Renal fibrosis ↑ Cell death |
[161] |
| 5/6 nephrectomy-Induced CKD | Tubular epithelial cells Interstitial fibroblasts |
↑ Renal fibrosis | [166] | |
| STZ-induced DN | Podocytes | ↑ Inflammation ↑ Fibrosis ↓ Renal function |
[167] | |
| Lupus Nephritis | Mesangial cells | ↑ Inflammation | [168] | |
| Skin | Psoriasis | Keratinocytes | ↑ Cell proliferation | [169,170] |
| Bone | RA | Synovial fibroblasts Osteoclasts Osteoblasts Chondrocytes |
↑ Inflammation | [155] |
| Spondyloarthritis | Synovial fluid monocytes Synovial fibroblasts Osteoblasts |
↑ Inflammation ↑ Osteoblastogenesis |
[171] | |
| Osteoporosis | Osteoclasts Osteoblasts |
↑ Osteoclastogenesis ↓ Osteoblastogenesis |
[172] | |
| Osteoarthritis | Synovial fibroblasts Chondrocytes |
↑ Inflammation ↓ Chondrogenesis ↑ Osteoblastogenesis |
[156] | |
| Intervertebral Disc (IVD) Herniation | Disc Cells | ↑ Inflammation | [173] |
↑ = increased; ↓ = decrease.