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Inhibitory effect of Rb1 (A,D), Rb2 (B,E), and Rc (C,F) on the OATP1B1- and OATP1B3-mediated uptake of valsartan. OATP1B1- and OATP1B3-mediated valsartan uptake was calculated by subtracting valsartan uptake (5 μM) by HEK293-mock cells from valsartan uptake (5 μM) by HEK293-OATP1B1 and -OATP1B3 cells, respectively. Data points represent the mean ± SD from triplicate measurements.
