Table 3.
Ginsenosides | Pharmacokinetic Parameters | ||||
---|---|---|---|---|---|
AUC (ng∙h/mL) | Cmax (ng/mL) | Tmax (h) | MRT (h) | T1/2 (h) | |
Rb1 | 454.57 ± 111.33 | 17.84 ± 2.34 | 3.33 ± 1.15 | 17.13 ± 2.09 | 16.87 ± 5.81 |
Rb2 | 282.80 ± 58.90 | 10.02 ± 1.04 | 3.33 ± 1.15 | 18.61 ± 1.43 | 30.19 ± 5.48 |
Rc | 320.75 ± 97.23 | 11.67 ± 2.49 | 3.33 ± 1.15 | 18.35 ± 1.89 | 24.24 ± 7.51 |
Rd | 163.83 ± 39.07 | 5.10 ± 0.74 | 2.17 ± 1.76 | 20.84 ± 1.68 | 43.49 ± 17.54 |
PPD | 542.01 ± 141.09 | 20.56 ± 9.47 | 16.50 ± 12.48 | 21.56 ± 3.31 | 26.95 ± 18.33 |
PPT | 429.91 ± 105.75 | 16.97 ± 8.99 | 16.50 ± 12.48 | 23.12 ± 2.26 | 46.38 ± 13.27 |
Data represent mean ± SD of four rats per group. AUC: area under the plasma concentration-time curve from 0 to 48 h Cmax: maximum plasma concentration; Tmax: time to reach Cmax; MRT: Mean residence time; T1/2: Half-life.