Table 4.
Pharmacokinetic parameters of valsartan and Rc following intravenous injection of valsartan at a dose of 1 mg/kg in rats.
| Valsartan | Rc | |||
|---|---|---|---|---|
| Parameters | Control | Rc Treatment | Parameters | Rc Treatment |
| T1/2 (h) | 2.41 ± 1.30 | 3.30 ± 1.51 | T1/2 (h) | 27.51 ± 4.26 |
| C0 (ng/mL) | 400.66 ± 77.85 | 1451.25 ± 998.21 | C0 (μM) | 34.04 ± 5.22 |
| AUC24h (ng·h/mL) | 639.41 ± 80.71 | 808.86 ± 111.90 | AUC24h (μM·h) | 748.59 ± 184.79 |
| AUC∞ (ng·h/mL) | 657.34 ± 84.89 | 836.42 ± 112.34 | AUC∞ (μM·h) | 1064.50 ± 324.96 |
| MRT (h) | 2.27 ± 0.67 | 2.94 ± 1.52 | MRT (h) | 38.50 ± 5.11 |
| CL (mL/h/kg) | 25.66 ± 3.50 | 20.18 ± 2.86 | ||
| Vd (L/kg) | 57.14 ± 13.24 | 57.65 ± 27.32 | ||
Data represent mean ± SD of three rats per group T1/2: elimination half-life; C0: initial plasma concentration at 1 h; AUC24h or AUC∞: Area under plasma concentration-time curve from zero to 24 h or infinity; MRT: mean residence time; CL: systemic clearance; Vd: Volume of distribution.