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. 2020 Feb 10;25(3):757. doi: 10.3390/molecules25030757

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Quercetin inhibited TGF-β1-induced EMT. (A) Experimental setup. (B) Western blot results showed that quercetin also regulated TGF-β1-induced EMT markers. (C) Treatment of TGF-β1 also changed the morphology of HaCaT. Further, quercetin induced morphological recovery. Scale bars: 50 μM. (D–I) Quantification of hRPTECs viability by MTT assay. (J,K) A wound-healing assay was conducted to evaluate the TGF-β1-induced EMT migration ability; quercetin attenuated EMT-induced migration in HaCaT cells. (L) Quercetin inhibited the invasion capacity of EMT-induced HaCaT cells. Data are the means ± SEM. * p < 0.05, and *** p < 0.001 vs. the corresponding control (without TGF-β1 and quercetin); ^# p < 0.05 vs. the corresponding control (with TGF-β1 and without quercetin).