Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of combretastatin A-4 (CA-4) derivatives. Reagents and conditions: (a) K2CO3 and DMF, RT 1 h., then BrCH2COEt, RT 24 h, 94%. (b) NaOH and EtOH, RT 1 h, 91%. (c) l-amino ester, EDCI·HCl, DMAP and DMF, 0 °C, 2 h, then RT 2 h. (d) LiOH and MeOH/H2O, RT 1 h. (e) d-amino ester, EDCI·HCl, DMAP and DMF, 0 °C, 2 h, then RT 2 h.
