Table 2.
Fold change in amino acids that are significantly altered in SPTB placenta.
| Pathway | Biochemical Name | Fold Change (Preterm/Term) | q-Value |
|---|---|---|---|
| Glycine, Serine and Threonine Metabolism | glycine | 1.25 | 0.0168 |
| betaine | 1.22 | 0.0473 | |
| betaine aldehyde | 2.22 | 0.0228 | |
| serine | 1.26 | 0.0159 | |
| threonine | 1.39 | 0.0064 | |
| N-acetylthreonine | 1.20 | 0.0469 | |
| N-acetylalanine | 1.43 | 0.007 | |
| aspartate | 1.32 | 0.0227 | |
| asparagine | 1.45 | 0.0057 | |
| Glutamate Metabolism | glutamate | 1.21 | 0.0217 |
| glutamine | 1.33 | 0.0271 | |
| gamma-aminobutyrate (GABA) | 1.61 | 0.0228 | |
| glutamate, gamma-methyl ester | 1.87 | 0.0168 | |
| N-acetylhistidine | 1.85 | 0.007 | |
| imidazole propionate | 3.25 | 0.0152 | |
| 4-imidazoleacetate | 0.51 | 0.0457 | |
| Lysine Metabolism | lysine | 1.24 | 0.0195 |
| N-6-acetyllysine | 1.45 | 0.0467 | |
| 2-aminoadipate | 1.79 | 0.0007 | |
| glutarate (pentanedioate) | 1.77 | 0.0028 | |
| pipecolate | 1.58 | 0.0278 | |
| Phenylalanine and Tyrosine Metabolism | phenylalanine | 1.31 | 0.0167 |
| tyrosine | 1.31 | 0.0115 | |
| 3-(4-hydroxyphenyl) lactate | 1.43 | 0.0207 | |
| N-formylphenylalanine | 3.10 | 0.0064 | |
| indoleacetate | 0.22 | 0.0064 | |
| 3-indoxyl sulfate | 0.62 | 0.0261 | |
| C-glycosyltryptophan | 1.35 | 0.0125 | |
| Leucine, Isoleucine and Valine Metabolism | leucine | 1.30 | 0.0096 |
| isoleucine | 1.24 | 0.0114 | |
| 3-hydroxy-2-ethylpropionate | 1.28 | 0.0387 | |
| ethylmalonate | 1.21 | 0.0351 | |
| valine | 1.36 | 0.0096 | |
| N-acetylvaline | 1.29 | 0.0228 | |
| isobutyrylcarnitine | 2.21 | 0.007 | |
| Methionine, Cytosine, SAM and Taurine Metabolism | methionine | 1.34 | 0.0128 |
| N-acetylmethionine | 1.44 | 0.0064 | |
| N-formylmethionine | 1.27 | 0.035 | |
| methionine sulfoxide | 3.75 | 0.0136 | |
| N-acetylmethionine sulfoxide | 4.52 | 0.0064 | |
| 2-aminobutyrate | 1.27 | 0.0342 |
Relative values of differentially expressed metabolites in SPTB placenta expressed as fold change of controls. All values are significantly different between preterm and term placenta, q ≤ 0.05.