Table 4.
Fold change in sterols and steroids in placenta.
| Pathway | Biochemical Name | Fold Change (Preterm/Term) | q-Value |
|---|---|---|---|
| Sterol | cholesterol | 1.86 * | 0.0136 |
| 7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca) | 0.81 | 0.0548 | |
| 4-cholesten-3-one | 1.87 * | 0.0016 | |
| 7-hydroxycholesterol (alpha or beta) | 3.49 | 0.0666 | |
| Steroid | 5-alpha-pregnan-3-beta,20-beta-diol monosulfate (1) | 1.02 | 0.1813 |
| 5-alpha-pregnan-3-beta,20-alpha-diol disulfate | 0.46 * | 0.0064 | |
| 5-alpha-pregnan-3(alpha or beta),20-beta-diol disulfate | 0.79 | 0.0638 | |
| pregnen-diol disulfate | 0.23 | 0.0009 | |
| pregnanediol-3-glucuronide | 0.77 | 0.066 | |
| progesterone | 1.37 * | 0.0347 | |
| cortisone | 0.29 * | 0.0011 | |
| dehydroisoandrosterone sulfate (DHEA-S) | 0.40 * | 0.0019 | |
| 16-a-hydroxy DHEA 3-sulfate | 0.41 * | 0.0079 | |
| androsterone sulfate | 1.23 | 0.1259 | |
| 4-androsten-3-beta,17beta-diol disulfate (1) | 0.09 * | 0.0001 | |
| 4-androsten-3-beta,17beta-diol disulfate (2) | 0.17 * | 0.0002 | |
| estrone | 0.45 * | 0.0064 | |
| pregnanolone/allopregnanolone sulfate | 0.64 * | 0.0192 |
Relative values of differentially expressed metabolites in SPTB placenta expressed as fold change of controls. * significant difference in preterm compared to control, q ≤ 0.05.