Table 3.

Pairwise comparison of score distribution in the NF1 protein domain. Results of Dunn’s test corrected for multiple comparisons with the Benjamini-Hochberg method are shown.

VEST3 Scores Score Comparison INTER DOMAINS	Median Difference	Adjusted p Value
RAS-GAP vs. CRAL-TRIO	0.133	<0.0001
RAS-GAP vs. PH LIKE	0.061	0.1102
RAS-GAP vs. ARMADILLO	0.126	<0.0001
RAS-GAP vs. NO FUNCTION	0.1595	<0.0001
CRAL-TRIO vs. PH LIKE	−0.072	0.0498
CRAL-TRIO vs. ARMADILLO	−0.007	0.7220
CRAL-TRIO vs. NO FUNCTION	0.0265	0.3105
PH LIKE vs. ARMADILLO	0.065	0.0405
PH LIKE vs. NO FUNCTION	0.0985	0.0009
ARMADILLO vs. NO FUNCTION	0.0335	0.0174
REVEL Scores Score Comparison INTER DOMAINS	Median Difference	p Value
RAS-GAP vs. CRAL-TRIO	0.3435	<0.0001
RAS-GAP vs. PH LIKE	0.0365	0.1087
RAS-GAP vs. ARMADILLO	0.3695	<0.0001
RAS-GAP vs. NO FUNCTION	0.3445	<0.0001
CRAL-TRIO vs. PH LIKE	−0.307	0.0001
CRAL-TRIO vs. ARMADILLO	0.026	0.5751
CRAL-TRIO vs. NO FUNCTION	0.001	0.3637
PH LIKE vs. ARMADILLO	0.333	<0.0001
PH LIKE vs. NO FUNCTION	0.308	<0.0001
ARMADILLO vs. NO FUNCTION	−0.025	0.4453
ClinPred Scores Score Comparison INTER DOMAINS	Median Difference	p Value
RAS-GAP vs. CRAL-TRIO	0.0365	0.013
RAS-GAP vs. PH LIKE	0.056	0.066
RAS-GAP vs. ARMADILLO	0.03	0.0002
RAS-GAP vs. NO FUNCTION	0.101	<0.0001
CRAL-TRIO vs. PH LIKE	0.0195	0.8558
CRAL-TRIO vs. ARMADILLO	−0.0065	0.8558
CRAL-TRIO vs. NO FUNCTION	0.0645	0.0283
PH LIKE vs. ARMADILLO	−0.026	0.8558
PH LIKE vs. NO FUNCTION	0.045	0.0253
ARMADILLO vs. NO FUNCTION	0.071	<0.0001