Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The binding mechanism of LPS for TLR4 activation. A series of events takes place prior to LPS recognition by the TLR4-MD2 complex. (1) LBP extracts LPS from the bacterial membrane and (2) transfers it to membrane anchored CD14, where it binds to the hydrophobic pocket located at the N terminus and forms a monomeric complex. (3) CD14 facilitates LPS transfer to the TLR4-MD2 complex where it initiated the intracellular pathway.
