Table 1.

3D structures of human TLR4 domains available in PDB.

PDB ID	Method	Resolution	Length	Domain	Ligand	Mutations	Ref.
2Z62	X-ray	1.70 Å	27–228	TLR4-ECD/MD2	Eritoran	-	[13]
2Z63	X-ray	2.00 Å	27–527	TLR4-ECD/MD2	Eritoran	-	[13]
2Z65	X-ray	2.70 Å	27–228	TLR4-ECD/MD2	Eritoran	-	[13]
2Z66	X-ray	1.90 Å	381–627	TLR4-ECD/MD2	Eritoran	-	[13]
3FXI	X-ray	3.10 Å	27–631	TLR4-ECD/MD2	LPS	-	[12]
3UL7	X-ray	2.37 Å	28–226	TLR4-ECD	-	F63W	[50]
3UL8	X-ray	2.50 Å	27–228	ECD	-	V134L	[50]
3UL9	X-ray	2.45 Å	28–228	ECD	-	M141E	[50]
3ULA	X-ray	3.60 Å	27–228	ECD	-	F63W	[50]
4G8A	X-ray	2.40 Å	23–629	TLR4-ECD/MD2	LPS	D299G/T399I	[51]
5NAM	NMR	-	623–670	TM Domain	-	-	[17]
5NAO	NMR	-	623–657	TM Domain	-	-	[17]