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A schematic diagram of the four different functional motifs of the mammalian FoxO family members (FoxOs). For humans, FoxO1, FoxO3, FoxO4, and FoxO6 proteins are 655 aa, 673 aa, 505 aa, and 492 aa in size, respectively. The functional domains are the forkhead domain, nuclear localization, nuclear export, and a transactivation domain.
