Table 1.

NTRK fusions in CNS tumors.

Tumor Entity	NTRK Fusions Frequency	Most Frequently Reported NTRK Fusions
Glioblastoma	1.1% (Frattini et al.) [134] 1.1% (Shah et al.) [135] 2.6% (Zheng et al.) [124] 1.2% (Kim et al.) [136] 1.7% (Ferguson et al.) [133]	BCAN-NTRK1 NFASC-NTRK1 ARHGEF2-NTRK1 CHTOP-NTRK1 GKAP-NTRK2 KCTD8-NTRK2 TBC1D2-NTRK2 EML4-NTRK3
Non-brainstem high-grade glioma	10%–40% (Wu et al.)# [121]	ETV6-NTRK3 TPM3-NTRK1 BTBD1-NTRK3 VCL-NTRK2 AGBL4-NTRK2
DIPG°	4% (Wu et al.) [121]
Pilocytic astrocytoma	16.6% (Ferguson et al.) [133] 3.1% (Jones et al.) [114]	BCAN-NTRK1 NACC2-NTRK2 QKI-NTRK2
Anaplastic astrocytoma	2.3% (Ferguson et al.) [133]	NOS1AP-NTRK2
Glioma NOS	4.1% (Ferguson et al.) [133]	SQSTM1-NTRK2
Low-grade glioma	0.7% (Zhang et al.) [112] 0.43% (Stransky et al.) [72] 4.3% (Ferguson et al.) [133]	ETV6-NTRK3 AFAP1-NTRK2 VCAN-NTRK2
High-grade glioneuronal tumor	Case report (Kurozumi et al.) [127]	ARHGEF2-NTRK1
Ganglioglioma	Case report (Prabhakaran et al.) [124]	TLE4-NTRK2

# Age-dependent frequency (highest rate was observed in <3yy patients). ° Diffuse Intrinsic Pontine Glioma.