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. 2020 Jan 27;21(3):818. doi: 10.3390/ijms21030818

Figure 5.

Figure 5

Hepatic Altered passive anaphylaxis (PSA but not PCA) in Mpst-KO mice. (A) Analysis of rectal temperatures in IgE-antigen-dependent PSA for WT, Mpst (1st)-KO, and Cth-KO mice after antigen challenge. Differences between pre-sensitized versus not pre-sensitized (vehicle alone) measurements were significant at ### p < 0.001 as well as those between genotypes at $$$ p < 0.001 in a two-way repeated-measured ANOVA with Bonferroni’s multiple comparison test (Differences in each time point were significant at * p < 0.05, ** p < 0.01, and *** p < 0.001). (B) Analysis of ear edema in IgE-antigen-induced PCA in WT, Mpst-KO, and Cth-KO mice after antigen challenge. Differences in Evans blue dye extravasation between left (not pre-sensitized) and right ears (pre-sensitized with anti-DNP IgE) were evaluated. The ratio differences were significant (* p < 0.05 and *** p < 0.001, pre-sensitized versus not pre-sensitized) in ratio paired t-tests. Differences in the ratios were not significant between the genotypes in a one-way ANOVA with Tukey’s multiple comparison test.