Table 1.
Inheritance of the Mpst and Cth mutant alleles in mice.
| Parental Genotypes | Genotypes of Offsprings (≥3-week-old) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | × | Female | Total Litter No. |
Average Litter Size |
Mpst-WT | Mpst-Het | Mpst-KO | Sex Ratio Male:Female |
||||||||||
| Mpst | Cth | Mpst | Cth | Cth-WT | Cth-Het | Cth-KO | Cth-WT | Cth-Het | Cth-KO | Cth-WT | Cth-Het | Cth-KO | ||||||
| Mpst single mutant | ||||||||||||||||||
| Het (1st) | WT | 27 | 5.1 ± 2.6 | 59 | 78 | 52:85 | ||||||||||||
| Het (1st) | Het (1st) | 81 | 5.7 ± 2.2 | 114 | 234 | 112 | 244:216 | |||||||||||
| KO (1st) | KO (1st) | 5 | 5.2 ± 1.8 | 26 | 16:10 | |||||||||||||
| Het (2nd) | WT | 14 | 5.5 ± 2.0 | 37 | 40 | 41:36 | ||||||||||||
| Het (2nd) | Het (2nd) | 17 | 5.0 ± 2.3 | 28 | 36 | 21 | 35:50 | |||||||||||
| KO (2nd) | KO (2nd) | 10 | 4.0 ± 2.0 | 40 | 21:19 | |||||||||||||
| Het (3rd) | WT | 9 | 3.6 ± 2.4 | 16 | 16 | 16:16 | ||||||||||||
| Het (3rd) | Het (3rd) | 30 | 5.1 ± 2.0 | 30 | 73 | 49 | 83:69 | |||||||||||
| KO (3rd) | KO (3rd) | 15 | 5.4 ± 2.4 | 81 | 39:42 | |||||||||||||
| Mpst (1st)/Cth double mutant | ||||||||||||||||||
| Het | KO | Het | KO | 11 | 4.6 ± 1.6 | 12 | 25 | 14 | 27:24 | |||||||||
| KO | Het | KO | Het | 29 | 5.8 ± 2.4 | 50 | 87 | 32 | 88:81 | |||||||||
| KO | KO | KO | KO | 8 | 3.6 ± 1.9 | 29 | 18:11 | |||||||||||
Total litter numbers, average litter size (mean ± SD), and numbers of genotyped offsprings from the indicated crosses are shown.