Evaluation of the MHT therapeutic process in multiple applications by BLI and 18F-FDG-PET. (A) BLI images of experimental groups at 13th (baseline), 22nd, and 32nd day after tumor induction, BLI signal changes according to the number of MHT applications. (B) Evaluation of BLI signals percentual after multiple applications of MHT therapeutic process. (C) Illustrative 18F-FDG-PET images fused to MRI templates of animals not submitted to tumoral induction (sham), animals submitted to tumor induction after three MHT applications, before (baseline) and post-treatment through 18F-FDG-PET.